Antigen-Stimulated Dissociation of BCR mIg from Ig-α/Ig-β

Pre-BCR signals and the control of Ig gene rearrangements.

Progenitor B lymphocytes that successfully assemble a heavy chain gene encoding an immunoglobulin capable of pairing with surrogate light chain proteins trigger their own further differentiation by signaling via the pre-BCR complex. The pre-BCR signals several rounds of proliferation and, in this expanded population, directs a complex, B cell-specific set of epigenetic changes resulting in alle...

BCR ubiquitination controls BCR-mediated antigen processing and presentation.

BCR-mediated antigen processing occurs at immunologically relevant antigen concentrations and hinges on the trafficking of antigen-BCR (Ag-BCR) complexes to class II-containing multivesicular bodies (MVBs) termed MIICs. However, the molecular mechanism underlying the trafficking of Ag-BCR complexes to and within MIICs is not well understood. In contrast, the trafficking of the epidermal growth ...

Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex

The B cell receptor for antigen (BCR) is a complex of membrane immunoglobulin (mIg) and at least two other proteins, Ig alpha (mb-1) and Ig beta (B29). This complex promotes surface expression of the BCR and acts to transduce an activation signal. We have used a system of mu heavy chain constructs transfected into murine B cell lines to probe structure-function relationships in the BCR complex....

Antigen-stimulated Human T Cells (ctla-4) on Cytokine Production by Receptor-1/ig-like Transcript 2 and Cd152 Dual Effect of Cd85/leukocyte Ig-like

Basal Ig /Ig Signals Trigger the Coordinated Initiation of Pre-B Cell Antigen Receptor-Dependent Processes